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We excluded patients with DM, alcohol use, or hepatitis B/C

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Some of the more commonly reported include: Joint and Muscle Related Symptoms Joint hypermobility Joint and muscle pain Frequent sprains Dislocations Spinal curve changes such as scoliosis or kyphosis Skin Related Symptoms Soft velvety-like skin Skin hyperextensibility Fragile skin that tears or bruises easily Slow wound healing Some people with EDS may also experience cardiovascular issues such as arterial fragility, gastrointestinal issues, or bowel/bladder problems

These findings may partly explain the mechanism of Th17 cells rapid response after APAP challenge

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After being washed three times in PBS for 5 min each time, the tissue sections were blocked in 5% bovine serum albumin for 1 h and were incubated with primary antibodies at 4 C overnight